Hotspots of biogeochemical activity linked to aridity and plant traits across global drylands.

Perennial plants create productive and biodiverse hotspots, known as fertile islands, beneath their canopies. These hotspots largely determine the structure and functioning of drylands worldwide. Despite their ubiquity, the factors controlling fertile islands under conditions of contrasting grazing by livestock, the most prevalent land use in drylands, remain virtually unknown. Here we evaluated the relative importance of grazing pressure and herbivore type, climate and plant functional traits on 24 soil physical and chemical attributes that represent proxies of key ecosystem services related to decomposition, soil fertility, and soil and water conservation. To do this, we conducted a standardized global survey of 288 plots at 88 sites in 25 countries worldwide. We show that aridity and plant traits are the major factors associated with the magnitude of plant effects on fertile islands in grazed drylands worldwide. Grazing pressure had little influence on the capacity of plants to support fertile islands. Taller and wider shrubs and grasses supported stronger island effects. Stable and functional soils tended to be linked to species-rich sites with taller plants. Together, our findings dispel the notion that grazing pressure or herbivore type are linked to the formation or intensification of fertile islands in drylands. Rather, our study suggests that changes in aridity, and processes that alter island identity and therefore plant traits, will have marked effects on how perennial plants support and maintain the functioning of drylands in a more arid and grazed world.

Distribution, Invasion History, and Ecology of Non-native Pine Bark Beetles (Coleoptera: Curculionidae: Scolytinae) in Southern South America.

The growth of international trade, coupled with an expansion of large-scale pine plantations in South America during the second half of the twentieth century, has significantly increased the opportunities for the invasion of forest insects. Bark beetles (Coleoptera: Curculionidae, Scolytinae) are a large and diverse group of insects, commonly recognized as one of the most important tree mortality agents in coniferous forests worldwide and an important group among invasive forest species. In this study, we combined data from field sampling with published records of established non-native pine bark beetles, to describe their distribution and invasion history in pine plantations across southern South America, reviewing the available information on their phenology and host range. We obtained records of established populations of six Eurasian species distributed in two major regions: the southwest region comprises plantations in Chile and the Argentine Patagonia, with four bark beetle species: Hylastes ater, Hylastes linearis, Hylurgus ligniperda, and Orthotomicus laricis; the northeastern zone includes northeastern Argentina, Uruguay, and southern Brazil, and includes three bark beetle species: Cyrtogenius luteus, H. ligniperda, and O. erosus. The establishment of non-native populations across the study area began in the 1950s, and from the 1980s onwards, there has been an exponential increase in introductions. We predict that several of these species will continue spreading across South America and that new species will continue arriving. We highlight the importance of international collaboration for early detection and management of non-native pine bark beetles.

Actualización de la Epidemiología de Tratamientos Quirúrgicos Maxilofaciales en Hospital Público de Santiago de Chile: Estudio Comparativo - Retrospectivo de 4 Años / Epidemiological Update of Maxillofacial Surgical Treatments in a Public Hospital in Santiago de Chile: A Comparative Retrospective Study of 4 Years

La cirugía maxilofacial es una especialidad médico quirúrgica que se encarga tanto del diagnóstico como del tratamiento de enfermedades que afecta al territorio craneofacial. En Chile existen pocos estudios epidemiológicos en cirugía maxilofacial que describan con detalle el tipo de intervenciones realizadas más allá del trauma maxilofacial, y que además involucren el período por pandemia COVID-19. El objetivo del estudio fue actualizar la epidemiología de resolución quirúrgica bajo anestesia general en el Hospital San José de Santiago de Chile entre los años 2018 y 2021 y compararlo con el estudio realizado en mismo recinto entre los años 2007 y 2013. Se realizó un estudio retrospectivo con 607 pacientes. Se recopiló información de acuerdo a edad, género del paciente y tipo de intervención. Del total de intervenciones realizadas, 176 (29%) correspondieron a trauma maxilofacial y 431 (71%) a cirugías de etiología no traumática. Edad promedio de 38,7 años. Proporción entre el sexo masculino y femenino de 1,28:1. La fractura más frecuente fue la mandibular (59,66%), seguida de la orbito cigomática (23,86%) y la panfacial (4,55%). En las cirugías de etiología no traumática predominaron las intervenciones por dismorfosis dentofaciales (23,2%), seguido tumores de los maxilares (20,41%), lesiones orales (18,56%), defocaciones dentarias (16,24%), infecciones (8,81%), patologías de articulación temporomandibular (8,35%) y finalmente retiro de material de osteosíntesis (4.41%). Las intervenciones de etiología no traumática y la resolución de fracturas mandibulares fueron los procedimientos más realizados por la unidad. El conocimiento de estos datos y la comparación con el estudio anterior permite observar el cambio en la epidemiologia, que puede explicarse por la pandemia por COVID-19. Considerando lo anterior, ambos tipos de intervenciones deben ser abordadas de manera integral y con las condiciones adecuadas. Para ello es importante enfocar los recursos en esas áreas y desarrollar mayor entrenamiento en las mismas.

Maxillofacial surgery is a medical- surgical specialty that deals with both diagnosis and treatment of diseases affecting the craniofacial territory. In Chile there are few epidemiological studies in maxillofacial surgery that describe in detail the type of interventions performed beyond maxillofacial trauma, and that also involve the COVID-19 pandemic period. The aim of the study was to update the epidemiology of surgical resolution under general anesthesia at the Hospital San José in Santiago de Chile between 2018 and 2021 and to compare it with the study performed at the same hospital between 2007 and 2013. A retrospective study was performed with 607 patients. Information was collected according to age, patient gender and type of intervention. Of the total number of interventions performed, 176 (29%) corresponded to maxillofacial trauma and 431 (71%) to surgeries of non-traumatic etiology. Average age of 38.7 years. Male to female sex ratio of 1.28:1. The most frequent fracture was mandibular (59.66%), followed by orbito-zygomatic (23.86%) and panfacial (4.55%). In surgeries of non-traumatic etiology, interventions for dentofacial dysmorphosis predominated (23.2%), followed by tumors of the jaws (20.41%), oral lesions (18.56%), dental defocations (16.24%), infections (8.81%), temporomandibular joint pathologies (8.35%) and finally removal of osteosynthesis material (4.41%). Interventions of non-traumatic etiology and resolution of mandibular fractures were the procedures most performed by the unit. The knowledge of these data and the comparison with the previous study allows us to observe the change in epidemiology, which can be explained by the COVID-19 pandemic. Considering the above, both types of interventions should be approached in a comprehensive manner and with the appropriate conditions. To this end, it is important to focus resources in these areas and to develop more training in them.

New Resinogalea species from Araucaria araucana resin in Chile and reclassification of the genus in the Cryptocaliciomycetidae.

Araucaria araucana is an ancient conifer, native to the mountain ranges in Chile and Argentina. These trees host a large number of organisms, mainly insects, strongly or even exclusively associated with them. The recent emergence of a novel canker disease on A. araucana has emphasised the importance of fungi associated with these iconic trees and has resulted in the discovery of various new species. In this study, we considered the identity of an unknown calicioid fungus consistently found on resin on the branches of A. araucana. Preliminary phylogenetic analyses placed isolates in the recently described sub-class Cryptocaliciomycetidae, closest to Cryptocalicium blascoi. However, the morphology of the ascomata and its occurrence in a unique niche suggested that the closest relative could be Resinogalea humboldtensis (Bruceomycetaceae, incertae sedis), a fungus with similar sporing structures found on resin of Araucaria humboldtensis in New Caledonia. There are no living cultures or sequence data available for either R. humboldtensis or its supposed closest relative, Bruceomyces castoris, precluding sequence-based comparisons. Morphological comparisons of the sporing structures on A. araucana confirmed that the ascomatal morphology of our unknown calicioid fungus and R. humboldtensis are almost identical and resemble each other more so than B. castoris or Cr. blascoi. A phylogenetic analysis based on the small subunit (SSU), internal transcribed spacer (ITS) and large subunit (LSU) rDNA regions resolved our strains into two clades with Cr. blascoi as its closest relative. Further analyses applying the Genealogical Concordance Phylogenetic Species Recognition (GCPSR) based on ITS, mini chromosome maintenance protein complex (MCM7), RNA polymerase II second largest subunit (RPB2) and translation elongation factor 1-alpha (TEF) gene regions, confirmed that strains represent two new species. Based on our morphological observations and phylogenetic analyses, we introduce two new Resinogalea species, R. araucana and R. tapulicola, and reclassify the genus in the subclass Cryptocaliciomycetidae.

Langerhans cell histiocytosis in the mandibular condyle and ramus. Endoscopic diagnosis. Case report / Histiocitosis de células de Langerhans en cóndilo y rama mandibular. Diagnóstico por vía endoscópica. Reporte de un caso

Langerhans cell histiocytosis (LCH) is a rare disease caused by uncontrolled proliferation and accumulation of immature bone marrow-derived myeloid dendritic cells. It is common in the pediatric population under 15 years of age and usually affects bones such as the skull, femur and mandibular body. This study presents the case of a 6-year-old female patient, with a bone lesion in the right mandibular ramus and condyle at an unusual location. A sample of the pathological tissue was taken by intraoral endoscopy to avoid comorbidities and esthetic sequelae. After a joint medical evaluation, the lesion was diagnosed as a monofocal LCH with special site involvement, establishing a single systemic treatment with indomethacin, as opposed to the chemotherapy regimen recommended by the International Histiocyte Society, in order to reduce the adverse effects of the latter. Two months after the beginning of the pharmacological treatment, reosification of the affected area was observed, with no recurrences after the end of the treatment. (AU)

La histiocitosis de células de Langerhans (LCH) es una afección rara originada por proliferación y acumulación descontrolada de células dendríticas mieloides inmaduras derivadas de la médula ósea. Su presentación es común en población pediátrica menor a 15 años, y suele afectar a huesos como el cráneo, fémur y cuerpo mandibular.En esta publicación se presenta el caso de un paciente de género femenino de 6 años, con lesión ósea en rama y cóndilo mandibular derecho de localización poco frecuente. Destaca la toma de muestra del tejido patológico mediante vía endoscópica intraoral con el fin de evitar comorbilidades y secuelas estéticas. Después de una evaluación médica conjunta, se diagnosticó como LCH monofocal con compromiso de sitio especial, estableciendo un tratamiento único de forma sistémica con indometacina, diferente a la quimioterapia recomendada por la Sociedad Internacional de Histiocitosis, de tal forma que disminuya los efectos adversos de esta. Se observó a los 2 meses de iniciado el tratamiento farmacológico reosificación de la zona afectada y sin recidivas posterior al término de este. (AU)

Cantolisis Lateral como Complemento al Acceso Transconjuntival en Fracturas de Órbita, Reporte de Casos

El acceso transconjuntival asociado a cantotomía lateral ha sido utilizado para permitir una mejor visualización de fracturas del piso de órbita. Esta técnica ha reportado entropión, ectropión y complicaciones en el reposicionamiento tarsal. Para disminuir la morbilidad descrita, hemos complementado este acceso con otra técnica denominada "Cantolisis Lateral" la que ha sido ampliamente utilizada como tratamiento de urgencia para hematoma retrobulbar, con pocos reportes sobre su utilidad en el tratamiento de las fracturas orbitarias. Reportamos los resultados post operatorios de la aplicación de la técnica cantolisis lateral como complemento al acceso transconjuntival en una serie de casos de 16 pacientes. La distopía cantal y la discontinuidad del tarso inferior fueron las complicaciones más frecuentes reportadas. Sin embargo, los pacientes no se percataron de ellas. No se reportaron ectropión ni entropión.

Transconjunctival approach associated with lateral canthotomy has been used to allow a better visualization of orbital floor fractures. This technique has reported entropion, ectropion and complications in tarsal repositioning. To decrease the described morbidity, we have complemented this approach with another technique called "Lateral Cantholysis" which has been widely used as an emergency treatment for retrobulbar hematoma, with few reports about its usefulness in the treatment of orbital fractures. We report the postoperative results of the application of the lateral cantholysis technique as a complement to the transconjunctival approach in a case series of 16 patients. Cantal dystopia and lower tarsal discontinuity were the most frequent complications reported. However, patients were not aware of them. No ectropion or entropion were reported.

Grazing and ecosystem service delivery in global drylands.

Grazing represents the most extensive use of land worldwide. Yet its impacts on ecosystem services remain uncertain because pervasive interactions between grazing pressure, climate, soil properties, and biodiversity may occur but have never been addressed simultaneously. Using a standardized survey at 98 sites across six continents, we show that interactions between grazing pressure, climate, soil, and biodiversity are critical to explain the delivery of fundamental ecosystem services across drylands worldwide. Increasing grazing pressure reduced ecosystem service delivery in warmer and species-poor drylands, whereas positive effects of grazing were observed in colder and species-rich areas. Considering interactions between grazing and local abiotic and biotic factors is key for understanding the fate of dryland ecosystems under climate change and increasing human pressure.

Cistoadenoma de glándula salival menor en paladar: Reporte de dos casos y revisión de la literatura

El cistoadenoma es un tumor epitelial benigno de baja frecuencia en glándulas salivales, que habitualmente se presenta como una masa de crecimiento lento. En glándulas salivales menores se localiza habitualmente en labio, paladar y mucosa yugal, cuyo diagnóstico diferencial representa un desafío desde el punto de vista clínico. El propósito de este reporte es presentar 2 casos de cistoadenoma en paladar, con énfasis en sus características clínicas y diagnóstico diferencial.

Cystadenoma is an uncommon benign epithelial tumor of the salivary glands, which usually appears as a slow-growing mass. In minor salivary glands, it is usually located in the lip, palate and buccal mucosa, whose differential diagnosis is a clinical challenge. The purpose of this report is to present 2 cases of palate cystadenoma, with emphasis on their clinical characteristics and differential diagnosis.

Richness, not evenness, varies across water availability gradients in grassy biomes on five continents.

We sought to understand the role that water availability (expressed as an aridity index) plays in determining regional and global patterns of richness and evenness, and in turn how these water availability-diversity relationships may result in different richness-evenness relationships at regional and global scales. We examined relationships between water availability, richness and evenness for eight grassy biomes spanning broad water availability gradients on five continents. Our study found that relationships between richness and water availability switched from positive for drier (South Africa, Tibet and USA) vs. negative for wetter (India) biomes, though were not significant for the remaining biomes. In contrast, only the India biome showed a significant relationship between water availability and evenness, which was negative. Globally, the richness-water availability relationship was hump-shaped, however, not significant for evenness. At the regional scale, a positive richness-evenness relationship was found for grassy biomes in India and Inner Mongolia, China. In contrast, this relationship was weakly concave-up globally. These results suggest that different, independent factors are determining patterns of species richness and evenness in grassy biomes, resulting in differing richness-evenness relationships at regional and global scales. As a consequence, richness and evenness may respond very differently across spatial gradients to anthropogenic changes, such as climate change.

Tumor Odontogénico Adenomatoide Quístico, presentación inusual. Reporte de dos casos

RESUMEN: El tumor odontogénico adenomatoide es un tumor benigno, poco común, que corresponde al 2-7% de los tumores odontogénicos. Se presenta con mayor prevalencia en la segunda década de vida y se ubica preferentemente en maxilar anterior. Es una lesión encapsulada, no agresiva, de crecimiento lento, que puede pasar desapercibida durante años. Deriva del epitelio odontogénico, y se caracteriza histológicamente por células epiteliales dispuestas en nidos, remolinos o cordones con escaso tejido conjuntivo. Puede presentar estructuras canaliculares un patrón ductiforme, con calcificaciones y presenta cápsula. El presente estudio reporta dos casos, el primero es una mujer de 30 años y el segundo el de un hombre de 36 años, ambos con un tumor odontogénico adenomatoide ubicado en zona maxilar anterior derecha, asintomático, sin asociación con diente incluido y de presentación quística a nivel imagenológico e histopatológico. Se discuten características clínicas, radiográficas, histopatológicas y terapéuticas de los casos.

ABSTRACT: Adenomatoid odontogenic tumor is a benign, rare tumor that accounts for 2-7% of odontogenic tumors. It appears with greater prevalence in the second decade of life and is located preferentially in the anterior maxilla. It is a slow-growing, non-aggressive, encapsulated lesion that can go unnoticed for years. It is derived from the odontogenic epithelium, and is characterized histologically by epithelial cells arranged in nests, eddies, or cords with little connective tissue. It may have canalicular structures and a ductiform pattern, with calcifications and it has a capsule. The present study reports two cases, the first is a 30-year-old woman and the second is a 36-year-old man, both with an adenomatoid odontogenic tumor located in the right anterior maxillary area, asymptomatic, without association with an included tooth and cystic presentation at the imaging and histopathological levels. The clinical, radiographic, histopathological and therapeutic characteristics of the cases are discussed.

Artrocentesis en el tratamiento de artritis séptica en articulación temporomandibular: reporte de un caso / Arthrocentesis in the treatment of septic arthritis in the temporomandibular joint: a case report

Objetivo: El objetivo de este reporte de caso es presen- tar a la artrocentesis como una alternativa quirúrgica mínima- mente invasiva en el tratamiento de la artritis séptica tempo- romandibular. Caso clínico: Un paciente hombre de 26 años con an- tecedente de flegmón perimandibular derecho tratado, acude a la Unidad Hospitalaria de Cirugía Maxilofacial por dolor articular temporomandibular, impotencia funcional y trismus, a un mes de haber sido dado de alta de un primer cuadro infec- cioso. Luego de los exámenes clínicos y complementarios, se diagnostica artritis séptica de articulación temporomandibular derecha, la cual fue tratada quirúrgicamente mediante dos ar- trocentesis acompañadas de terapia farmacológica (AU)

Aim: The aim of this case report is to present arthrocen- tesis as a minimally invasive surgical alternative in the treat- ment of temporomandibular septic arthritis. Clinical case: A 26-year-old male patient, with a his- tory of treated right perimandibular phlegmon, came to the Maxillofacial Surgery Hospital Unit due to temporomandibu- lar joint pain, functional impairment and trismus, one month after having recovered from his first infectious process. After clinical and complementary examinations, septic arthritis of the right temporomandibular joint was diagnosed, which was treated surgically by means of two arthrocenteses and phar- macological therapy (AU)

Reconstrucción de Fracturas Orbitarias Utilizando Tecnología Digital Tridimensional: Una forma de Optimizar Resultados

RESUMEN: La reconstrucción de las paredes orbitarias fracturadas es compleja debido a la gran cantidad de parámetros volumétricos que posee. Una restitución inadecuada de ellas habitualmente está asociada a secuelas postquirúrgicas en el paciente. El contar con herramientas que optimicen la restitución de la forma anatómica de la órbita en su reconstrucción es de vital importancia, y la utilización de nuevas tecnologías ha permitido mejorar los resultados quirúrgicos, tanto anatómicos como funcionales. El objetivo de este artículo es mostrar dos herramientas quirúrgicas que permiten optimizar los resultados terapéuticos en pacientes con fractura de órbita, que son el modelo estereolitográfico con imagen en espejo y la tomografía computada intraoperatoria. Se presentan las características de estas herramientas, su utilización en tres casos de pacientes con fractura orbitaria y los resultados obtenidos en el post operatorio.

ABSTRACT: The reconstruction of fractured orbital walls is complex due to the many volumetric parameters involved. An inadequate restitution of these walls may be associated with postsurgical sequelae in the patient. Is vitally important to count with tools that optimize the restitution of the orbit's anatomic shape during its reconstruction, and the use of new technologies has allowed the improvement of the surgical results, both anatomical and functional. The aim of this article is to show two surgical tools that allow to optimize the therapeutic results in patients with orbital fracture, which are stereolithographic models with mirror image technique, and intraoperative computed tomography. Their characteristics, their use in three cases of patients with orbital fractures, and the postoperative results are shown.

Comparative Efficacy of a High-Dose vs Standard-Dose Hepatitis B Revaccination Schedule Among Patients With HIV: A Randomized Clinical Trial.

Importance: Active immunization for hepatitis B virus (HBV) infection is recommended in patients living with HIV. Limited evidence is available about the most appropriate regimen of HBV vaccination among those who have not responded to an initial schedule. Objective: To determine the efficacy of a high-dose schedule compared with a standard dose of HBV vaccination. Design, Setting, and Participants: This double-masked, parallel-group, randomized controlled trial included patients living with HIV at a single outpatient HIV and hepatology clinic in Chile for whom previous HBV vaccination had failed. Patients with hepatitis B surface antibody (anti-HBs) titers less than 10 IU/L after an initial HBV vaccination regimen were included. Consecutive patients were recruited between December 2013 and March 2018. Data were analyzed in June 2018 using intention-to-treat analysis. Intervention: The high-dose HBV vaccination group consisted of 3 doses of 40 µg recombinant hepatitis B vaccine at 0, 1, and 2 months. The standard-dose group received 3 doses 20 µg each at 0, 1, and 2 months. Main Outcomes and Measures: Primary outcome was the serologic response to HBV vaccination (anti-HBs greater than 10 IU/L) 4 to 8 weeks after completion of the schedule. Secondary outcomes were anti-HBs greater than 100 IU/L and seroprotective anti-HBs at 1 year follow up. Results: A total of 107 patients underwent randomization (55 to the standard-dose group, 52 to the high-dose group); 81 (75.7%) were men, and the mean (SD) patient age was 47.0 (13.3) years. Nearly all patients were receiving antiretroviral therapy (105 patients [98%]) and 92 patients (86%) had an undetectable HIV viral load. Mean (SD) CD4 count was 418 (205) cells/mm3. There were no differences in baseline characteristics between groups. Serological response in the high-dose group was found in 36 of 50 patients (72%; 95% CI, 56.9%-82.9%) compared with 28 of 55 patients in the standard-dose group (51%; 95% CI, 37.1%-64.6%) (odds ratio, 2.48; 95% CI, 1.02-6.10; P = .03). Mean (SD) anti-HB levels were 398.0 (433.4) IU/L in the high-dose group and 158.5 (301.4) IU/L in the standard-dose group (P < .001). Of patients with a serological response in the high-dose group, 29 of 36 (80.6%) had anti-HBs titers greater than 100 IU/L compared with 14 of 28 responders (50.0%) in the standard-dose group (P = .02). At 1-year follow-up, 20 of 25 patients (80.0%) with a serological response in the high-dose group had protective anti-HBs vs 9 of 23 patients (39.1%) in the standard-dose group (P = .01). Conclusions and Relevance: The results of this randomized clinical trial suggest that use of a high-dose regimen for HBV revaccination for patients with HIV achieves a higher and longer-lasting serological response as compared with a standard-dose regimen. Trial Registration: ClinicalTrials.gov Identifier: NCT02003703.

Transferability of PCR-based diagnostic protocols: An international collaborative case study assessing protocols targeting the quarantine pine pathogen Fusarium circinatum.

Fusarium circinatum is a harmful pathogenic fungus mostly attacking Pinus species and also Pseudotsuga menziesii, causing cankers in trees of all ages, damping-off in seedlings, and mortality in cuttings and mother plants for clonal production. This fungus is listed as a quarantine pest in several parts of the world and the trade of potentially contaminated pine material such as cuttings, seedlings or seeds is restricted in order to prevent its spread to disease-free areas. Inspection of plant material often relies on DNA testing and several conventional or real-time PCR based tests targeting F. circinatum are available in the literature. In this work, an international collaborative study joined 23 partners to assess the transferability and the performance of nine molecular protocols, using a wide panel of DNA from 71 representative strains of F. circinatum and related Fusarium species. Diagnostic sensitivity, specificity and accuracy of the nine protocols all reached values >80%, and the diagnostic specificity was the only parameter differing significantly between protocols. The rates of false positives and of false negatives were computed and only the false positive rates differed significantly, ranging from 3.0% to 17.3%. The difference between protocols for some of the performance values were mainly due to cross-reactions with DNA from non-target species, which were either not tested or documented in the original articles. Considering that participating laboratories were free to use their own reagents and equipment, this study demonstrated that the diagnostic protocols for F. circinatum were not easily transferable to end-users. More generally, our results suggest that the use of protocols using conventional or real-time PCR outside their initial development and validation conditions should require careful characterization of the performance data prior to use under modified conditions (i.e. reagents and equipment). Suggestions to improve the transfer are proposed.

Fracturas Mandibulares Conminutadas por Impacto de Proyectil Balístico: Propuesta de Tratamiento Inicial Mediante Método de Fijación Alternativo / Mandibular Fractures Comminuted by Ballistic Projectile Impact: Initial Treatment Proposal Using Alternative Fixation Method

RESUMEN: El trauma maxilofacial por arma de fuego representa un desafío terapéutico principalmente debido a la gran conminución de tejidos que genera. Específicamente, en casos de fracturas mandibulares conminutadas, las modalidades de tratamientos incluye la reducción cerrada, fijación con tutor externo, fijación interna con alambres y reducción abierta y fijación interna utilizando placas y tornillos. El objetivo del presente trabajo es describir un tratamiento inicial con un método de fijación para fracturas mandibulares conminutadas como dispositivo alternativo al tutor externo clásicamente utilizado. Se desarrolla una revisión de la literatura actual acerca del tratamiento inicial o de urgencia de fracturas mandibulares conminutadas por impacto de proyectil balístico, haciendo énfasis en las indicaciones de cada modalidad de tratamiento y sus respectivas ventajas y desventajas. Luego se describe detalladamente el proceso de confección de un método de fijación alternativo junto con la exposición de casos clínicos donde fue utilizado como alternativa de tratamiento. La reducción y fijación obtenida por el dispositivo presentado logra resultados satisfactorios, sin encontrarse diferencias significativas a los elementos de fijación clásicos. Tanto el uso de placas de reconstrucción como el de tutor externo constituyen alternativas válidas para el tratamiento de fracturas mandibulares conminutadas. El dispositivo descrito y utilizado en los pacientes es una alternativa eficiente, de fácil confección y bajo costo económico demostrando buenos resultados en relación a la consolidación de fracturas conminutadas. Se debe conocer las indicaciones para la aplicación de cada modalidad de tratamiento.

ABSTRACT: Ballistic maxillofacial trauma represents a challenge for surgeons because of the important comminution process it presents. Specifically, in cases of mandibular comminuted fractures, the different treatment modalities include closed reduction, external fixation and internal fixation. The purpose of this case series is to describe an initial treatment modality, with a fixation method for comminuted mandibular fractures as an alternative for the classic external fixator. We conducted a literature review about the initial treatment for ballistic comminuted mandibular fractures, emphasizing indications of each treatment modality and their respective advantages and disadvantages. Next, we described the preparation process of an alternative fixation method along with a case series, where it was used as a therapeutical alternative. The reduction as well the fixation achieved by the external fixator, showed satisfactory results without significant differences noted with traditional fixation methods. Both, reconstruction plates and external fixators, are valid alternatives for treating comminuted mandibular fractures. The method described and used in these patients is and efficient alternative, easy to make and at a low cost, with good results in relation to fracture consolidation. We propose that every treatment modality and its indications should be evaluated in order to treat each case adequately.

Presence of anti-HBc is associated to high rates of HBV resolved infection and low threshold for Occult HBV Infection in HIV patients with negative HBsAg in Chile.

HBV-HIV coinfection is prevalent. Frequently, anti-HBc is the only serological marker of HBV, which can be indicative of HBV resolved infection, when found together with anti-HBs reactivity; or present as "isolated anti-HBc," related to HBV occult infection with presence of detectable DNA HBV, more prevalent in HIV-positive individuals. Regional data about this condition are scarce. Anti-HBc rapid test has been used as screening, but its performance has not been described in HIV-positive patients. The aim of this study was determine prevalence of anti-HBc in HIV-positive patients, serological pattern of HBV resolved infection and isolated anti-HBc, evaluating presence of HBV occult infection. Assess anti-HBc rapid test compared to ECLIA. Methods included measurement of anti-HBc and anti-HBs in HIV-positive patients with negative HBsAg. Serum HBV DNA quantification and HBV booster vaccination to "isolated anti-HBc" individuals. Detection of anti-HBc by rapid test and ECLIA. In 192 patients, prevalence of anti-HBc was 42.7% (82/192); associated to male gender, drug use, men-sex-men, positive-VDRL, and longer time HIV diagnosis. 34.4% (66/192) had presence of anti-HBs, mean titers of 637 ui/ml. Isolated anti-HBc in 8.3% (16/192), associated to detectable HIV viral load and no-use of HAART; in them, HBV DNA was undetectable, and 60% responded to HBV vaccination booster. Anti-HBc rapid test showed low sensibility (32.9%) compared to ECLIA. These results show that prevalence of anti-HBc in HIV-positive individuals is high, in most cases accompanied with anti-HBs as HBV resolved infection. Low prevalence of "isolated anti-HBc," with undetectable HBV DNA, and most had anamnestic response to HBV vaccination; suggest low possibility of occult HBV infection. Anti-HBc rapid test cannot be recommended as screening method for anti-HBc.

Epidemiología de Tratamientos Quirúrgicos Maxilofaciales en un Hospital Público en Santiago de Chile: Estudio Retrospectivo de 5 Años / Epidemiology of Maxillofacial Surgical Treatments in a Public Hospital in Chile: A 5-Year Retrospective Study

Pocos estudios epidemiológicos en cirugía maxilofacial describen en forma detallada las características de los pacientes y los tipos de intervención realizadas. El objetivo de este estudio fue conocer la epidemiología de las intervenciones quirúrgicas maxilofaciales realizadas bajo anestesia general en el Hospital Clínico San José. Se realizó un estudio retrospectivo con 599 pacientes entre los años 2007 y 2013. Se recopiló información de acuerdo a edad, género del paciente y tipo de intervención. Del total de intervenciones realizadas, 335 (56%) correspondieron a trauma maxilofacial y 264 (44%) a cirugías de etiología no traumática. Edad promedio de 38 años. Proporción entre el sexo masculino y femenino de 2,05:1. La fractura más prevalente fue la mandibular con un 49,8%, luego la orbitocigomatica 28,3%, panfacial 13,7%, huesos de órbita 2,98%, Le Fort 2,7%, cigomático 2,1% y nasoorbitoetmoidal con 0,43%. En tanto las cirugías de etiología no traumática, infecciones 12,1%, tumores 12%, dismorfosis cráneofacial 11,8%, exodoncias múltiples en pacientes con desórdenes neurológicos 2,3%, reconstrucciones estéticas 2,1%, patologías de articulación temporomandibular 1,6%, distintas lesiones orales 1,1%, displasias 0,3% y retiro de osteosíntesis 0,3%. La reducción y fijación con osteosíntesis de fracturas faciales fueron los procedimientos más realizados por la unidad. El conocimiento de estos datos permite saber en qué áreas enfocar el presupuesto del departamento, y en que se requiere mayor especialización. Además de mostrar la necesidad de mayor número de horas de pabellón requeridos.

Few epidemiological studies in maxillofacial surgery describe in detail the characteristics of patients and types of intervention undertaken. The aim of this study was to determine the epidemiology of maxillofacial surgical procedures performed under general anesthesia at the Clinical Hospital San José. A retrospective study, which included 599 patients, was carried out between 2007 and 2013, according to information obtained on age, patient sex and type of intervention. Of the total procedures performed, 335 (56%) were maxillofacial trauma and 264 (44%) were non-traumatic surgeries. Average age was 38 years old. Ratio between male and female was 2.05:1. The most prevalent was mandibular fracture with 49.8%, subsequently orbito zigomatic fractures with 28.3%, panfacial with 13.7%, orbital bones 2.98%, Le Fort 2.7%, and zygomatic bone 2.1% and naso orbitoetmoidal with 0.43%. In both non traumatic surgeries the following was reported, infections 12.1%, tumors, 12%, craniofacial dysmorphosis 11.8%, multiple extractions in patients with neurological disorders 2.3%, aesthetic reconstructions 2.1%, temporomandibular joint disorders 1.6%, various oral lesions 1.1%, dysplasias 0.3% and osteosynthesis withdrawal 0.3%. Most frequent procedures performed were reduction and osteosynthesis fixation of facial fractures. Knowledge of these data provides information as to which areas to focus the department's budget on, areas in which greater specialization is required, and reinforcing the need for requirement of additional hours in the operating room.

Fibroma osificante juvenil trabecular mandibular: presentación de un caso con reconstrucción inmediata mediante un injerto libre de la cresta ilíaca y costocondral / Juvenile trabecular ossifying fibroma: presentation of a case with immediate costochondral-iliac crest reconstruction

El fibroma osificante juvenil (FOJ) es una lesión fibro-ósea benigna pero con potencial biológico agresivo que afecta al esqueleto craneofacial. Su evolución clínica es rápida, manifestándose principalmente por una asimetría facial de poco tiempo de evolución. Radiográficamente es una lesión radiolúcida uni o multilocular bien definida con contenido radiopaco variable. El tratamiento puede variar dependiendo de las características clínicas, imagenológicas e histopatológicas específicas de cada lesión, sin embargo, un tratamiento agresivo con resección es el más indicado. Se presenta un caso de un niño con extenso FOJ trabecular (FOJT) mandibular. Se realizó la resección completa de la lesión con un margen de seguridad y reconstrucción inmediata con un injerto de la cresta ilíaca y costocondral. Se realizaron controles postoperatorios durante 7 años en los que no se observaron signos de recidiva asociados a una reconstrucción funcional y estética exitosa (AU)

Juvenile ossifying fibroma (JOF) is a benign fibro-osseous lesion with an aggressive biological behavior in most cases. The clinical course is fast, manifesting mainly as a facial asymmetry. Radiographically it presents as a well-defined, uni- or multi-locular radiolucent lesion with variable radiopaque areas. Treatment may vary depending on the clinical, imaging and histopathological specific pattern, but generally an aggressive treatment with resection is the most appropriate. We report a case of a child with an extensive trabecular JOF (TFOJ) of the mandible. We performed a complete resection of the lesion with a security margin and immediate reconstruction with a costochondral-iliac crest bone graft. Postoperative controls were performed for seven years, during which there were no signs of recurrence, demonstrating a successful functional and anesthetic reconstruction (AU)

Optimización de la dosificación de vancomicina en pacientes críticos mediante el análisis de sus niveles plasmáticos / Dosage of vancomycin in critically ill patients: analysis of plasmatic levels

Los pacientes críticos se caracterizan por la presencia de diversos factores que pueden alterar la cinética de vancomicina, antibiótico ampliamente utilizado en las unidades de cuidados intensivos para el tratamiento de infecciones producidas por Staphylococus aureus meticilino resistente. Pacientes y métodos: Este estudio evaluó las dosis de vancomicina comúnmente utilizadas en la Unidad de Paciente Critico del Hospital Dr. Gustavo Fricke y la estrategia de administración inicial de carga endovenosa de vancomicina en dichos pacientes. Resultados: El 55,3 por ciento de los niveles plasmáticos obtenidos fueron menores de 15 mcg/mL. Bajo la estrategia de administración de carga endovenosa, solo el 13,3 por ciento de los resultados se encontraron por debajo de dicho valor. Los resultados fueron dependientes estadísticamente de la edad, índice de masa corporal y función renal del paciente. Conclusiones: La carga endovenosa de vancomicina permite alcanzar los niveles plasmáticos requeridos en pacientes críticos. Es necesario evaluar los factores de la edad, función renal e índice de masa corporal de los pacientes que se les administrará vancomicina y ajustar las dosis según las determinaciones periódicas de sus niveles plasmáticos.

Critically ill patients are characterized by the presence of various factors can alter the kinetics of vancomycin antibiotic widely used in intensive care units for treating infections caused by methicillin resistant Staphylococcusaureus. Patients and methods: This study evaluated vancomycin doses commonly used in critically ill patient Unit Dr. Gustavo Fricke Hospital and initial management strategy of charging intravenous vancomycin in such patients. Results: 55.3 percent of the plasmatic levels obtained were lower than 15 mcg / mL. Under load management strategy IV, 13.3 percent of the results were below this value. The results were statistically dependent on age, body mass index and renal function. Conclusions: The burden of vancomycin intravenously can achieve the required plasma levels in critically ill patients. It is necessary to evaluate the factors of age, renal function and body mass index of patients that will be administered according to vancomycin and adjust these measurements the periodic determination of plasma levels.